RAF Typhoon FGR4s have joined forces with French aircraft in a coordinated attack on an hidden munitions depot in Syria used by the IS group, as stated by the British defence ministry.
The facility, identified by surveillance, was assessed as storing arms and explosives, the statement said, and was located in hills just above the historic site of Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a number of access tunnels providing entry to the depot... preliminary assessments are that the objective was successfully hit," the ministry announced.
There was no evidence of any civilian impact in the attack on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - established extremist governance over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This action shows British leadership, and commitment to operate in unison with our partners, to eradicate any re-emergence of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the minister remarked.
RAF aircraft have carried out overwatch operations over Syria to "deter any attempted resurgence" of the group following its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to all the members of British forces participating in this strike for their skill and their valour," the Defence Secretary said. "Including them were thousands of British troops stationed over the festive period. This operation, to remove terrorist threats who endanger our safety, highlights how UK forces are ready to step up, continuously, ensuring Britain's security within its borders and powerful internationally."
Last December, the US military conducted what it termed a "massive strike" against Islamic State objectives in the country, following an attack killed two US servicemembers and a civilian interpreter in the Palmyra area.
The UN estimates Daesh still boasts between 5,000 and 7,000 militants in Syria and Iraq.